1.

Buffalo Sabres
 vs. Montreal Canadiens

October 10, 2008
Friday, 7:30 pm

 2.

Buffalo Sabres
 vs. Vancouver Canucks

October 17, 2008
Friday, 7:30 pm

 3.

Buffalo Sabres
 vs. Boston Bruins

October 21, 2008
Tuesday, 7:00 pm

 4.

Buffalo Sabres
 vs. Ottawa Senators

October 27, 2008
Monday, 7:00 pm

 5.

Buffalo Sabres
 vs. Tampa Bay Lightning

October 30, 2008
Thursday, 7:00 pm

 6.

Buffalo Sabres
 vs. Washington Capitals

November 1, 2008
Saturday, 7:00 pm

 7.

Buffalo Sabres
 vs. Atlanta Thrashers

November 7, 2008
Friday, 7:30 pm

 8.

Buffalo Sabres
 vs. St. Louis Blues

November 12, 2008
Wednesday, 7:00 pm

 9.

Buffalo Sabres
 vs. Columbus Blue Jackets

November 14, 2008
Friday, 7:30 pm

 10.

Buffalo Sabres
 vs. Philadelphia Flyers

November 21, 2008
Friday, 7:30 pm

 11.

Buffalo Sabres
 vs. New York Islanders

November 22, 2008
Saturday, 7:00 pm

 12.

Buffalo Sabres
 vs. Boston Bruins

November 26, 2008
Wednesday, 7:00 pm

 13.

Buffalo Sabres
 vs. Pittsburgh Penguins

November 28, 2008
Friday, 7:30 pm

 14.

Buffalo Sabres
 vs. Nashville Predators

December 1, 2008
Monday, 7:00 pm

 15.

Buffalo Sabres
 vs. Tampa Bay Lightning

December 10, 2008
Wednesday, 7:00 pm

 16.

Buffalo Sabres
 vs. Toronto Maple Leafs

December 12, 2008
Friday, 7:30 pm

 17.

Buffalo Sabres
 vs. New Jersey Devils

December 17, 2008
Wednesday, 7:00 pm

 18.

Buffalo Sabres
 vs. Los Angeles Kings

December 19, 2008
Friday, 7:30 pm

 19.

Buffalo Sabres
 vs. Pittsburgh Penguins

December 22, 2008
Monday, 7:00 pm

 20.

Buffalo Sabres
 vs. New York Islanders

December 27, 2008
Saturday, 7:00 pm

 21.

Buffalo Sabres
 vs. Washington Capitals

December 30, 2008
Tuesday, 7:00 pm

 22.

Buffalo Sabres
 vs. Ottawa Senators

January 6, 2009
Tuesday, 7:00 pm

 23.

Buffalo Sabres
 vs. New York Rangers

January 9, 2009
Friday, 7:30 pm

 24.

Buffalo Sabres
 vs. Carolina Hurricanes

January 17, 2009
Saturday, 7:00 pm

 25.

Buffalo Sabres
 vs. Toronto Maple Leafs

February 4, 2009
Wednesday, 7:30 pm

 26.

Buffalo Sabres
 vs. Montreal Canadiens

February 6, 2009
Friday, 7:30 pm

 27.

Buffalo Sabres
 vs. Ottawa Senators

February 11, 2009
Wednesday, 7:30 pm

 28.

Buffalo Sabres
 vs. San Jose Sharks

February 13, 2009
Friday, 7:30 pm

 29.

Buffalo Sabres
 vs. Carolina Hurricanes

February 15, 2009
Sunday, 6:00 pm

 30.

Buffalo Sabres
 vs. New York Rangers

February 21, 2009
Saturday, 7:00 pm

 31.

Buffalo Sabres
 vs. Anaheim Ducks

February 24, 2009
Tuesday, 7:00 pm

 32.

Buffalo Sabres
 vs. Montreal Canadiens

March 4, 2009
Wednesday, 7:30 pm

 33.

Buffalo Sabres
 vs. Phoenix Coyotes

March 6, 2009
Friday, 7:30 pm

 34.

Buffalo Sabres
 vs. Florida Panthers

March 12, 2009
Thursday, 7:00 pm

 35.

Buffalo Sabres
 vs. Atlanta Thrashers

March 14, 2009
Saturday, 7:00 pm

 36.

Buffalo Sabres
 vs. Philadelphia Flyers

March 20, 2009
Friday, 7:30 pm

 37.

Buffalo Sabres
 vs. Florida Panthers

March 25, 2009
Wednesday, 7:00 pm

 38.

Buffalo Sabres
 vs. Toronto Maple Leafs

March 27, 2009
Friday, 7:30 pm

 39.

Buffalo Sabres
 vs. New Jersey Devils

April 4, 2009
Saturday, 7:00 pm

 40.

Buffalo Sabres
 vs. Detroit Red Wings

April 6, 2009
Monday, 7:00 pm

 41.

Buffalo Sabres
 vs. Boston Bruins

April 11, 2009
Saturday, 4:00 pm